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3,3',5'-Triiodo-L-thyronine

Full Name
3,3',5'-Triiodo-L-thyronine (RE1037)
Background
3,3',5’-Triiodo-L-thyronine (Reverse T3), is a thyroid hormone generated by the deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3',5-triiodo-L-thyronine.  Reverse T3 positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.
Research Area Other/Reagents
Catalog Number RE1037
Alternate Name O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3; Reverse T3
Molecular Weight 650.97
Molecular Formula C₁₅H₁₂I₃NO₄
Appearance Off-white solid
InChi InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
MDL Number MFCD00036864
Purity ≥95%
Solubility DMSO (30 mg/ml)
Handling Protect from air and light
Storage Instruction Store at -20°C
Usage Statement Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses.
For Research Use Only. Not For Clinical Use Or Individual Users.

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