A gene is optimally expressed through the systematic design of the gene itself, vector, the host system, and culture conditions. The advantage of customized gene synthesis is that the desired DNA can be custom designed according to research needs, not limited by traditional cloning methods.
Codon optimization refers to the use of preferred codons, to simplify the secondary structure of post-transcriptional mRNA, remove motif, that is not conducive to high expression, and add a motif, that is conducive to high expression to adjust GC content and other methods to redesign genes. To maximize the expression level of synthetic genes in all existing expression systems and meet the needs of global researchers for efficient synthesis and expression of mitochondrial genes, Creative Biogene uses a professional software platform to provide efficient and accurate services for the design and optimization of mitochondrial genes and vectors. We can solve the problems in codon preference, mRNA secondary structure, GC content, removal of trans-acting elements and restriction sites that affect expression, and translation initiation and termination efficiency.
Creative Biogene gene design includes not only codon optimization, but also mRNA structure modification, translation initiation site optimization, and so on. Creative Biogene always provides you with customized services for mitochondrial research, and our one-stop research and analysis platform can meet all your research needs.
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