Kidney Diseases

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The kidney is a mitochondria-rich organ with high energy requirements in the body.

Abnormalities and dysfunction of renal mitochondria affect several cellular pathways, leading to increased oxidative stress, apoptosis, microvascular loss and fibrosis, all of which can impair kidney function.

Figure 1. The health and disease of the kidney are regulated by the pathophysiological conditions of mitochondria (Duann & Lin, 2017).

Mitochondria dysfunction gets involved in kidney diseases in the following aspects:

• mtDNA damage, reduced matrix density and impaired outer/inner membrane integrity.
• Changes in mitochondrial homeostasis, the molecular control of mitochondrial formation (biogenesis), morphology (fusion/division) and degradation (mitosis).
• Mitochondrial abnormalities and impaired homeostasis lead to bioenergetic impairment (reduced ATP production and calcium signaling), triggering oxidative stress and apoptosis.

Targeting mitochondria to study kidney disease is a novel and promising field.

Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated kidney diseases and possible interventions, with professional services and products to support your research.

Specific Kidney Diseases

Creative Biogene offers comprehensive testing services for the evaluation of a variety of kidney diseases.

You could benefit from our established models of kidney diseases. We offer comprehensive mitochondria-focused testings and services with the advantage of our cell-based and animal-based models.

Customized options exist if the diseases you focus on are not on the list. We have the capability of customizing our assays and models. Please do not hesitate to contact us if you require customized services.

Our Capabilities

In vivo/in vitro assessment of mitochondrial function can be a useful tool for mechanistic studies of kidney diseases, as well as for the evaluation of (novel) therapeutic interventions.

Creative Biogene provides rapid mitochondrial function testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.

Quotation and Ordering

If you have any special needs or questions regarding our services, please feel free to contact us. Creative Biogene looks forward to cooperating with you in the future.

Reference

1. Duann, P., & Lin, P.-H. (2017). Mitochondria Damage and Kidney Disease. In G. Santulli (Ed.), Mitochondrial Dynamics in Cardiovascular Medicine (Vol. 982, pp. 529-551).

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