Acute Kidney Injury
The kidney is a mitochondria-rich organ with high energy requirements in the body.
Abnormalities and dysfunction of renal mitochondria affect several cellular pathways, leading to increased oxidative stress, apoptosis, microvascular loss and fibrosis, all of which can impair kidney function.
Figure 1. The health and disease of the kidney are regulated by the pathophysiological conditions of mitochondria (Duann & Lin, 2017).
Mitochondria dysfunction gets involved in kidney diseases in the following aspects:
Targeting mitochondria to study kidney disease is a novel and promising field.
Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated kidney diseases and possible interventions, with professional services and products to support your research.
Creative Biogene offers comprehensive testing services for the evaluation of a variety of kidney diseases.
You could benefit from our established models of kidney diseases. We offer comprehensive mitochondria-focused testings and services with the advantage of our cell-based and animal-based models.
Customized options exist if the diseases you focus on are not on the list. We have the capability of customizing our assays and models. Please do not hesitate to contact us if you require customized services.
In vivo/in vitro assessment of mitochondrial function can be a useful tool for mechanistic studies of kidney diseases, as well as for the evaluation of (novel) therapeutic interventions.
Creative Biogene provides rapid mitochondrial function testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.
Oxygen Consumption Rate (OCR) Measurement
Fluorescent Reporters of Mitochondrial pH
Mitochondrial Membrane Potential (MMP)
Fission and Fusion
If you have any special needs or questions regarding our services, please feel free to contact us. Creative Biogene looks forward to cooperating with you in the future.
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