Figure 1. The Carnitine Shuttle.
L-carnitine is a ubiquitous trimethylated amino acid that is instrumental in the transport of long-chain fatty acids (LCFA) across the mitochondrial inner membrane.
Carnitine is also involved in the removal of accumulated toxic fatty acyl-coenzyme A (acyl-CoA) metabolites and contributes to a balance between free and acyl-CoA buffering. Carnitine is present as free carnitine (non-esterified molecule; FC) or acylated carnitine (esterified form; AC).
Accordingly, the AC/FC ratio is a measure of acylated carnitine relative to free carnitine. L-carnitine deficiency can increase the AC/FC ratio, leading to functional carnitine deficiency.
An increase in acylated carnitine levels can also be caused by other factors such as enzymatic changes in carnitine metabolism, which can lead to an increase in the AC/FC ratio.
Creative Biogene provides an accurate carnitine level testing service to precisely evaluate the metabolism changes induced by mitochondria dysfunction.
Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated diseases and possible interventions, with professional Biofluid Biochemistry assay services to support your research.
Creative Biogene provides rapid Biofluid Biochemistry testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.
|Biofluid Biochemistry||Metabolic Panel|
|Lactate and Pyruvate Levels|
|Plasma Amino Acid Profile|
|Urine Organic Acid Profile|
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