Carnitine Level
Creative Biogene provides a comprehensive range of Biofluid Biochemistry testing services to assist researchers in mitochondria-related disease studies.
Figure 1. The Carnitine Shuttle.
L-carnitine is a ubiquitous trimethylated amino acid that is instrumental in the transport of long-chain fatty acids (LCFA) across the mitochondrial inner membrane.
Carnitine is also involved in the removal of accumulated toxic fatty acyl-coenzyme A (acyl-CoA) metabolites and contributes to a balance between free and acyl-CoA buffering. Carnitine is present as free carnitine (non-esterified molecule; FC) or acylated carnitine (esterified form; AC).
Accordingly, the AC/FC ratio is a measure of acylated carnitine relative to free carnitine. L-carnitine deficiency can increase the AC/FC ratio, leading to functional carnitine deficiency.
An increase in acylated carnitine levels can also be caused by other factors such as enzymatic changes in carnitine metabolism, which can lead to an increase in the AC/FC ratio.
- Low AC/FC ratio → Healthy mitochondria
- High AC/FC ratio → Reduced ability of mitochondria to produce energy
Creative Biogene provides an accurate carnitine level testing service to precisely evaluate the metabolism changes induced by mitochondria dysfunction.
Technical Characteristics
- Carnitine is usually measured by examining the levels in blood and urine. We provide accurate determining methods through fully automated biochemical analysis and LC/MS.
- Easy-to-use assay kits are also available.
- Only a small quantity of samples is required.
- Creative Biogene will provide a full report of the experimental procedure, experimental data and analysis results.
Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated diseases and possible interventions, with professional Biofluid Biochemistry assay services to support your research.
Related Services
Creative Biogene provides rapid Biofluid Biochemistry testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.
Our Advantages
- Rich experience in mitochondrial biochemical assay analysis
- Outstanding research team
- Unique integrated service for mitochondrial research
- Reliable data and results
- Rapid turnaround and cost-effective
Quotation and Ordering
Creative Biogene has the most professional team to serve customers around the world. If you have any questions about the content of this service, please feel free to contact us. We look forward to your contact.
Reference
- Sharma, Shruti, and Stephen M. Black. "Carnitine homeostasis, mitochondrial function and cardiovascular disease." Drug Discovery Today: Disease Mechanisms 6.1-4 (2009): e31-e39.
For Research Use Only. Not For Clinical Use Or Individual Users.
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