A large proportion of drugs are withdrawn from the market every year because of the side effects that have not been found in the preclinical or mid-term. Usually, these side effects are cardiotoxicity and hepatotoxicity caused by mitochondrial dysfunction. Therefore, the determination of mitochondrial toxicity is very important in drug development, and the evaluation of mitochondrial toxicity in the early stage of drug development can prevent the waste of resources in later clinical research, thus saving development time and cost.
Figure 1. Processes related to mitochondrial dysfunction.
CD Mitochondria has established a complete and mature mitochondrial toxicity testing platform, which can provide a complete solution for in vitro mitochondrial safety analysis and determination of key parameters of mitochondrial function, and assist your drug development and evaluation.
Figure 2. Possible sites of mitochondrial function induced by heterologous organisms resulting in mitochondrial toxicity. (James H., et al. , 2006)
CD Mitochondria always provides you with customized services for mitochondrial research, and our one-stop research and analysis platform can meet all your research needs.
Detection of mitochondrial toxicity by oxygen sensitive probe based on fluorescence
This method is suitable for the analysis of mitochondria from different tissues.
CD Mitochondria has the most professional team to serve customers around the world. If you have any questions about the content of this service, please feel free to contact us. We look forward to your contact.