Neurodegeneration

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Table 1 Proteins/genes known to be mutated in
neurodegeneration

Neurodegenerative diseases (NDs) comprise a diverse set of pathological processes involving progressive neuronal dysfunction, degeneration and death, leading to incurable and debilitating diseases.

Many genetic factors have been identified (Table 1), and more importantly, almost all NDs exhibit impaired mitochondrial energy metabolism. As an example, dysfunction of respiratory chain complexes can all lead to different NDs (Table 2).

Therefore, mitochondrial gene expression profiles, biochemical and bioenergetic properties are the focus of research on NDs and are recognized indicators in disease mechanism and therapy studies.

Table 2 Relation between respiratory chain complex dysfunctions and NDs.

Complex I	Parkinson's disease (PD)
Complex II and III	Huntington's disease (HD)
Complex IV	Alzheimer's disease (AD)
α-ketoglutarate dehydrogenase	AD and PD

Figure 1. Respiratory chain complex (Connolly et al., 2018).

Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated NDs and possible interventions, with professional services and products to support your research.

Specific NDs

Creative Biogene offers comprehensive services for the evaluation of various NDs.

You could benefit from our established models of a variety of NDs. We offer comprehensive mitochondria-focused testings and services with the advantage of our cell-based and animal-based NDs models.

Customized options exist if the diseases you focus on are not on the list. We have the capability of customizing our assays and models. Please do not hesitate to contact us if you require customized services.

Our Capabilities

In vivo/in vitro assessment of mitochondrial function can be a useful tool for mechanistic studies of NDs, as well as for the evaluation of (novel) therapeutic interventions.

Creative Biogene provides rapid mitochondrial function testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.

Quotation and Ordering

If you have any special needs or questions regarding our services, please feel free to contact us. Creative Biogene looks forward to cooperating with you in the future.

Reference

1. Connolly, et al. (2018). Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death & Differentiation, 25(3), 542-572.

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