Cancer

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Cancer cells have a different metabolism than normal cells, which allows them to survive longer and grow faster. Resistance to apoptosis is a key feature of cancer cells, and given the importance of mitochondria in apoptosis, it is crucial to study the behavior of mitochondria in tumors.

Indeed, the relationship between cancer development and mitochondrial dysfunction is manifested in various ways:

• Warburg effect
• Mitochondrial gene mutations
• Mitochondrial biogenesis
• Mitochondria structural and functional abnormalities
• Cation Channels

In addition, nuclear gene mutations in conjunction with the following transcription factors and signaling pathways affecting mitochondrial function are also important in the development and metastasis of cancer.

• PI3K-AKT
• MAPK
• p53
• HIF1
• NF-κB
• STAT3

Therefore, mitochondria could be a potential target for cancer therapy.

Figure 1. Mitochondria-targeted Cancer Therapies (Klein, 2020).

Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated cancers and possible interventions, with professional services and products to support your research.

Cancer Models

You could also benefit from our established cancer models. Creative Biogene offers comprehensive mitochondria-focused tests and services with the advantage of our cell-based and animal-based models.

Our Capabilities

In vivo/in vitro assessment of mitochondrial function can be a useful tool for mechanistic studies of cancers, as well as for the evaluation of (novel) therapeutic interventions.

Creative Biogene provides rapid mitochondrial function testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.

Quotation and Ordering

If you have any special needs or questions regarding our services, please feel free to contact us. Creative Biogene looks forward to cooperating with you in the future.

Reference

1. Klein, Katherine, et al. "Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches." Frontiers in immunology 11 (2020).

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