Creative Biogene provides a way to detect cell death directly by MPTP, rather than relying solely on mitochondrial membrane potential. The detection process is rapid and sensitive, and the detection results of mitochondrial permeability transition pore can be used as an early marker of apoptosis.
Mitochondrial permeability transition pore (MPTP), also known as mitochondrial mega channel, composed of a variety of proteins, is a non-specific and highly conductive channel between the inner and outer membranes of mitochondria. MPTP participates in the substance release of mitochondria during cell death. In healthy cells, MPTP is between the on and off state; but in the process of cell death, MPTP significantly changes the permeability of mitochondria. When MPTP is activated, the mitochondrial membrane potential decreases, and cytochrome C is released.
Figure 1. Principle of mitochondrial permeability transition pore detection.
Creative Biogene provides direct detection of cell death by using rapid and sensitive MPTP detection, rather than relying solely on mitochondrial membrane potential. The fluorescent probe of membrane permeability detects MPTP's opening degree, which can then be further analyzed by fluorescence microscope and flow cytometry. Results can be used to study cell death, such as apoptosis and necrosis.
Creative Biogene provides custom services for mitochondrial research. Our one-stop research and analysis platform can meet all your research needs.
Creative Biogene seeks and provides the best product solutions for customers around the world, continuously improving the quality of products and services, and aims to provide you with the highest quality and latest overall solutions for mitochondrial biology.
Creative Biogene has the most professional team to serve customers around the world. If you have any questions about our services, please feel free to contact us. We look forward to hearing from you.