Mitochondrial permeability transition pore (MPTP), also known as mitochondrial mega channel, composed of a variety of proteins, is a non-specific and highly conductive channel between the inner and outer membranes of mitochondria. MPTP participates in the substance release of mitochondria during cell death. In healthy cells, MPTP is between the on and off state; but in the process of cell death, MPTP significantly changes the permeability of mitochondria. When MPTP is activated, the mitochondrial membrane potential decreases, and cytochrome C is released.
Figure 1. Principle of mitochondrial permeability transition pore detection.
CD Mitochondria provides direct detection of cell death by using rapid and sensitive MPTP detection, rather than relying solely on mitochondrial membrane potential. The fluorescent probe of membrane permeability detects MPTP's opening degree, which can then be further analyzed by fluorescence microscope and flow cytometry. Results can be used to study cell death, such as apoptosis and necrosis.
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