Mitochondrial Quality and Membrane Potential Detection

Relying on rich experience, mature platform, and professional team, Creative Biogene provides efficient and accurate mitochondrial membrane potential detection services to help global customers' apoptosis research.

A large number of studies have shown that mitochondria are closely related to apoptosis, in which the decrease of mitochondrial transmembrane potential (MMP) is considered one of the earliest events in the cascade of apoptosis. It occurs before the appearance of the characteristics of nuclear apoptosis (chromatin condensation, DNA fragmentation). Once the mitochondrial transmembrane potential collapses, apoptosis is irreversible.

Creative Biogene uses JC-1 to provide mitochondrial membrane potential detection services to customers around the world. JC-1 is an ideal fluorescent probe widely used to detect mitochondrial membrane potential ΔΨm, which can be used to detect cell, tissue, or purified mitochondrial membrane potential.

JC-1 has two states of monomer and polymer, and their emission spectra are different. In normal cells, the membrane potential of mitochondria is higher, and JC-1 aggregates in the matrix of mitochondria to form polymers, which can produce red fluorescence. In the early stage of apoptosis, the mitochondrial membrane potential decreases and JC-1 could not accumulate in the mitochondrial matrix. At this time, JC-1 is a monomer and could produce green fluorescence.

The decrease of cell membrane potential can be detected by the transformation of JC-1 from red fluorescence to green fluorescence, and the change of JC-1 fluorescence color can be used as an early detection index of apoptosis. The relative ratio of red and green fluorescence is often used to measure the proportion of mitochondrial depolarization.

General Strategy

Detection of Mitochondrial Quality and Membrane Potential

Creative Biogene always provides you with customized services for mitochondrial research, and our one-stop research and analysis platform can meet all your research needs.

Related Products

Creative Biogene seeks and provides the best product solutions for customers around the world, continuously expanding the quality of products and services, and aims to provide you with the highest quality and latest overall solutions for mitochondrial biology.

Our Advantages

  • Rich experience in detecting mitochondrial membrane potential
  • Outstanding research team
  • Unique integrated service for mitochondrial research
  • Reliable data and results
  • Rapid turnaround and cost-effective

Creative Biogene has the most professional team to serve customers around the world. If you have any questions about the content of this service, please feel free to contact us. We look forward to your contact.

For Research Use Only. Not For Clinical Use Or Individual Users.
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