Mitochondrial Physiological and Pathological Modifications

Creative Biogene provides global customers with multi-species mitochondrial epigenetic analysis and customizes the appropriate research route for you. To help customers solve the problem of mitochondrial epigenetics may be tissue-and cell-specific, and there are significant epigenetic differences between different types of cells even in the same tissue/organ. We are also committed to providing you with research services on the epigenetic characteristics of mitochondria under different physiological and pathological conditions.

Mitochondria provide essential intermediate metabolites for the nucleus, regulate and modify epigenetic markers, and participate in the epigenetic response of nuclear DNA and chromatin; in turn, mitochondria rely on the nucleus to promote most of their functional activities. The pathology most closely related to the epigenetic mechanism and easily affected by epigenetic pharmacology is cancer, and aging is one of the earliest physiological processes involving mitochondrial epigenetics. As early as the 1980s, studies have shown that aging plays an important role in changing the methylation state of the mitochondrial genome.

Figure 1. The epigenetic cross-talk between nucleus and mitochondria.(Castegna A., et al. 2015)

  • Two-way crosstalk between nuclear and mitochondrial DNA
  • Creative Biogene mainly provides research services on the physiological and biochemical processes involved in the two-way crosstalk between nuclear and mitochondrial DNA, such as anterograde regulation, retrograde response, histone modification, mtROS, mtDNA insertion in the nuclear genome and so on.

  • Mitochondrial epigenetics in pathological tissues of cancer
  • Creative Biogene has established a platform to study the association between key cancer gene expression and mtDNA methylation, providing customers with pathogenic gene mining, gene expression research, mtDNA methylation, and key gene association analysis, molecular regulation mechanism research and other services.

  • Mitochondrial DNA methylation and senescence
  • Creative Biogene provides professional mitochondrial DNA methylation and hydroxymethylation research services. Our scienetists have rich experience in association analysis and data analysis. They use our mature technology platform to provide faster and reliable correlation analysis services between mitochondrial DNA methylation and aging.

In addition to the above research services, we also provide more research services on physiological and pathological modifications of mitochondrial epigenetics. Including but not limited to the following.

  • Support species-specific mitochondrial epigenetic studies
  • Study on Mitochondrial epigenetics under different physiological and pathological conditions.
  • Analysis of the relationship between professional mitochondrial epigenetics and physiology and pathology.
  • Identification of epigenetic factors as targets of mitochondrial nuclear crosstalk.
  • The interaction mechanism model between mitochondria and nucleus was established.

Our Advantages

  • Rich experience in mitochondrial epigenetics research
  • Outstanding research team
  • Unique integrated service for mitochondrial research
  • Reliable data and results
  • Rapid turnaround and cost-effective

The services provided by Creative Biogene on mitochondrial epigenetics do not stop there. For more information, please contact us and we will be happy to answer any of your questions.


  1. Castegna A., et al. (2015). “ The mitochondrial side of epigenetics.” Physiol Genomics. 47(8): 299-307.
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