Special attention should be paid to lactate and pyruvate levels when performing biochemical tests of mitochondria.
Figure 1. Metabolic remodeling of cancer cells (Cannino et al., 2018).
Clinical experience has shown that patients with the mitochondrial disease tend to suffer from a condition known as lactic acidosis, which is an increased concentration of lactic acid in the body.
Lactate and pyruvate are acids found in the mitochondria. This ratio of lactate to pyruvate is usually increased in mitochondrial dysfunction due to changes in biochemical pathways. The lactate to pyruvate ratio is detected in the cerebrospinal fluid when neurological symptoms are also present.
Creative Biogene provides accurate lactate and pyruvate testing services to precisely evaluate the metabolism changes induced by mitochondria dysfunction.
Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated diseases and possible interventions, with professional Biofluid Biochemistry assay services to support your research.
Creative Biogene provides rapid Biofluid Biochemistry testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.
|Lactate and Pyruvate Levels
|Plasma Amino Acid Profile
|Urine Organic Acid Profile
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