Methylation and Hydroxymethylation

Creative Biogene has rich experience in studying mitochondrial DNA methylation and hydroxymethylation and extends the latest research methods. We can provide customers with the most comprehensive services for studying DNA methylation so that you can conduct the latest mitochondrial methylation and hydroxymethylation research at any time.

MtDNA methylation and hydroxymethylation are important components of Mitoepigenetics, which play an important role in maintaining normal cell function, genetic imprinting, embryonic development, and human tumorigenesis. The epigenetic modification of mtDNA, such as global methylation of mtDNA or methylation of specific sites, can combine with oxidative stress, drugs, and environmental exposure, resulting in corresponding physiological and pathological changes, and its mechanism needs to be further explored.

Figure 1. Mitochondrial DNA methylation.(Gao D., et al. 2017)

Creative Biogenes uses nucleic acids isolated from small samples to analyze the methylation and hydroxymethylation of the whole genome, carries out the study of methylation and hydroxymethylation of mitochondrial bases, and strives to establish a specific mtDNA methylation map and find specific biomarkers of mitochondrial epigenetic modification, which is of great significance for the prevention and detection of neurodegenerative diseases or cancer at the gene level. With the development of high-throughput sequencing technology, Creative Biogene uses advanced platforms to analyze events such as methylation and hydroxymethylation at the genome-wide level.

Service Content

The methylation technology for analysis of mtDNA is an important direction for the development of life science in the future. Creative Biogene team's research on mitochondrial DNA methylation and hydroxylation also includes, but is not limited to, the following.

  • Study on the role of mtDNA methylation from the activity of mitochondrial enzymes.
  • The possible signal pathway mechanism of epigenetic regulation of mtDNA.
  • Effect of mitochondrial epigenetic modification products.
  • An in-depth study of the metabolic response and its mechanism of nuclear line cross-talk.

Service Flow

Our Advantages

  • Rich experience in mitochondrial epigenetics research
  • Outstanding research team
  • Unique integrated service for mitochondrial research
  • Reliable data and results
  • Rapid turnaround and cost-effective

Creative Biogene adheres to the concept of providing customers with a high standard of one-stop service and also provides customers with more detailed research methods on mitochondrial DNA methylation. Click here to learn more.


  1. Jianji G., et al. (2018). “New progress in mitochondrial DNA epigenetics.” Journal of Toxicology. 32(3): 248-252.
  2. Gao D., et al. (2017). “Mitochondrial DNA methylation and related disease.” https://doi.org/10.1007/978-981-10-6674-0_9.
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