Mitochondrial respiratory chain complex I (NADH oxidase) and mitochondrial respiratory chain complex II (succinate dehydrogenase) are the main elements of the electron transport chain (ETC). Complex I catalyzes the oxidation of NADH and complex II catalyzes the oxidation of succinic acid to fumaric acid. Subsequently, coenzyme Q forms coenzyme QH2, and finally leads to the decrease of terminal electron receptor O2. Mitochondrial respiratory chain complex III (cytochrome c oxidoreductase) is an essential protein for mitochondrial oxidative phosphorylation. Mitochondrial respiratory chain complex III is the gatekeeper of the mitochondrial respiratory chain and the main source of the third reactive oxygen species. Mitochondrial respiratory chain complex IV (cytochrome c oxidase) is the terminal electron receptor of the mitochondrial electron transport chain. Complex IV converts O2 to H2O through the oxidation of cytochrome c, which is related to the synthesis of mitochondrial cell membrane ATP.
Mitochondrial respiratory chain complex V completes oxidative phosphorylation with the above four complexes to form ATP, which is called ATP synthetase, also known as the F0F1-ATP enzyme.
The inhibition of the activity of the mitochondrial respiratory chain complex will lead to severe mitochondrial dysfunction, and long-term inhibition may lead to nervous system diseases. Therefore, the activity of the mitochondrial respiratory chain complex is often used as an indicator of neuro deficits diseases caused by mitochondrial toxicity. The Creative Biogene detection platform uses biochemical methods to detect the activity of mitochondrial respiratory chain complex and ATP enzyme efficiently and accurately, which helps you to screen the inhibitors of mitochondrial respiratory chain complex more simply, quickly, and effectively.
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