The urine organic acid test is one of the primary means of assessing mitochondrial function by measuring metabolites from digestion, assimilation, metabolism and ATP production to assess the normalcy of metabolic pathways. When one or more pathways are not functioning properly, organic acids will "overflow" into the urine.
Various organic acids are involved in different metabolic reactions:
Adipic Acid (Adipate), Suberic Acid (Suberate), Sebacic Acid (Suberate), Ethylmalonic Acid (Ethylmalonate), Methylsuccinic Acid (Methylsuccinate), Ketone bodies (Acetoacetic Acid and Beta-Hydroxybutyrate), γ-Hydroxybutyric Acid and L-carnitine
Pyruvate, Lactate, and β-Hydroxybutyrate
Succinic Acid (Succinate), α-Ketoglutaric Acid, Citric Acid (Citrate), Aconitic Acid (Aconitate), Fumaric Acid (Fumarate), Malic Acid (Malate)
Lactate, Succinate, Fumarate, and Malate
Figure 1. Mitochondria at the crossroad of metabolic networks and signaling cascades (Cannino et al., 2018).
Creative Biogene provides accurate urine organic acid testing services to precisely evaluate the metabolism changes induced by mitochondria dysfunction.
Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated diseases and possible interventions, with professional Biofluid Biochemistry assay services to support your research.
Creative Biogene provides rapid Biofluid Biochemistry testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.
|Biofluid Biochemistry||Metabolic Panel|
|Lactate and Pyruvate Levels|
|Plasma Amino Acid Profile|
|Urine Organic Acid Profile|
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