Mitoepigenetics
Creative Biogene has a professional epigenetic research team to keep up with the latest developments in mitochondrial research. We can provide a comprehensive and in-depth mitoepigenetics analysis platform to help customers around the world carry out cutting-edge mitochondrial research.
Mitoepigentics refers to the epigenetic modification of genes encoded by mitochondria and the epigenetic regulation of mitochondria by other metabolites. There is a complex network of epigenetic regulation between mitochondria and nuclear genomes, which can participate in complex pathophysiological processes, such as neurodegenerative diseases, cancer or premature senility. Mitochondrial epigenetics has become a new and important content in the field of life science.
Four regulation modes of mitochondrial epigenetics
- The epigenetic mechanism of regulating nuclear gene expression can affect mitochondria by regulating the expression of nuclear-encoded mitochondrial genes.
- The methylation pattern of nuclear genes is determined by cell-specific mitochondrial DNA (mtDNA) content and mitochondrial activity.
- MtDNA mutations affect nuclear gene expression patterns and nuclear DNA (ncDNA) methylation levels.
- MtDNA itself is also modified by epigenetics.
Besides, exposure to environmental pollutants and dietary nutrition can also stimulate epigenetic modification of mitochondrial genes, thus affecting their gene expression.
Figure 1. The four elements of mitoepigenetics. (Manev, H., et al, 2013)
At present, our main services for mitochondrial epigenetics include mitochondrial DNA methylation and hydroxymethylation, physiological and pathological modification of mitochondrial epigenetics, and mitochondrial epigenetics are used as biomarkers and new therapeutic targets. The interaction between mitochondria and nuclei, the use of mitochondrial epigenetic products as biomarkers, and the effects of environment and nutritious diet on mitochondrial epigenetics are also services that Creative Biogene can provide to customers around the world.
Mitoepigenetics Related Services
Creative Biogene is committed to providing the best mitoepigenetics services to help you conduct cutting-edge mitochondrial research. In addition to the content displayed on our website, we also provide customized mitochondrial research services to meet your special requirements. If you have any needs or questions, please feel free to contact us.
Our Advantages
- Rich experience in mitochondrial epigenetics research
- Outstanding research team
- Unique integrated service for mitochondrial research
- Reliable data and results
- Rapid turnaround and cost-effective
Reference
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Manev. H., et al. (2013). “Progress in mitochondrial epigenetics.” Biomolecular Concepts. 4(4): 381-389.
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