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AT-101

Full Name
AT-101 (RE1017)
Background
AT-101 is not only an inhibitor of anti-apoptotic Bcl protein but also an inducer of pro-apoptotic proteins NOXA and PUMA. It induces apoptosis of drug-resistant multiple myeloma cell lines activated by the mitochondrial pathway.
Research Area Other/Reagents
Catalog Number RE1017
Alternate Name (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dim­ethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8­,8'-dicarboxaldehyde; (R)-Gossypol
Molecular Weight 518.56
Molecular Formula C₃₀H₃₀O₈
Appearance Light brown solid
InChi InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
Purity ≥98% by TLC
Solubility DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
Handling Protect from light and air
Storage Instruction Store at -20 ̊C
Usage Statement Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses.
For Research Use Only. Not For Clinical Use Or Individual Users.

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